Publications by authors named "R S Llewellyn"

Background: PAPP is widely used in Australia as a potent vertebrate bait, with potential for off-target ingestion and poisoning in domestic dogs. Whilst toxicosis and resulting methaemoglobinaemia is anecdotally known to occur, this is the first description in the literature. This study reports thirteen clinical cases of suspected Para-aminopropiophenone (PAPP) toxicity in dogs, with the aim of describing clinical presentation and current management of toxicosis in this species.

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Background: Low- and middle-income countries have a critical shortage of specialist anaesthetists. Most patients arriving for surgery are of low perioperative risk. Without immediate access to preoperative specialist care, an appropriate interim strategy may be to ensure that only high-risk patients are seen preoperatively by a specialist.

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Virtual fencing technology uses on-animal devices to communicate boundaries via a warning audio tone and electrical pulse signals. There is currently limited validation work on sheep. This study used modified cattle eShepherd virtual fencing neckbands on reduced-wool sheep with clipped necks to enable automated trials with small groups across both day and night.

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Article Synopsis
  • T cell checkpoint immunotherapies are effective for some patients, but many do not respond; targeting CD47 and SIRPα has shown promise in blood cancers but challenges remain in solid tumors due to CD47's presence in peripheral blood.
  • Researchers developed a bispecific antibody that targets both CD47 and PD-L1 to improve selectivity and treatment effectiveness by focusing on tumor cells in the tumor microenvironment (TME) while minimizing interactions with healthy cells like red blood cells.
  • The bispecific antibody showed improved activation of immune cells, enhancing antitumor effects and leading to unique immune responses, including increased CD8 T cell dynamics, in animal studies; promising results were also observed
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