Publications by authors named "R S Legro"
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common hormonal disorder linked to infertility, and its symptoms overlap with those of partial lipodystrophy, which is caused by variations in the LMNA gene.
- Researchers conducted genetic sequencing on two cohorts, comparing PCOS patients with healthy controls to investigate a potential connection between LMNA variations and the development of PCOS.
- Results showed a significant association between rare LMNA variants and PCOS in multiple cohorts, particularly among women exhibiting high triglycerides and insulin resistance, indicating a need to explore further genetic links to PCOS.
Objective: To compare pregnancy and neonatal outcomes in women with hyperandrogenic polycystic ovarian syndrome (PCOS) phenotypes compared with nonhyperandrogenic PCOS phenotypes.
Methods: We conducted a retrospective cohort study of participants in the PPCOS (Pregnancy in Polycystic Ovary Syndrome) I and II randomized controlled trials; all of the participants met the National Institutes of Health diagnostic criteria for PCOS and were then sorted into three of the four Rotterdam criteria categories based on medical interview, demographics, physical examination, and laboratory data. The two hyperandrogenic (A and B) Rotterdam categories were compared with the nonhyperandrogenic phenotype of PCOS (phenotype D).
Context: Previous studies have shown that the prevalence of polycystic ovary syndrome (PCOS) may vary according to race/ethnicity, although a few studies have assessed women of different ethnicities who live in similar geographic and socioeconomic conditions.
Objective: To determine the prevalence of PCOS in an unselected multiethnic population of premenopausal women.
Design: A multicenter prospective cross-sectional study.
Background: Abdominal obesity is associated with endothelial dysfunction and poorer vascular health. Avocado consumption improves postprandial endothelial function; however, the longer-term effects remain unclear. It was hypothesized that the daily addition of 1 avocado to a habitual diet for 6 months would improve flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity in individuals with abdominal obesity (waist circumference ≥35 in for women, ≥40 in for men), compared with a habitual diet low in avocados.
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