Tezepelumab inhibits highly functional truncated thymic stromal lymphopoietin in chronic rhinosinusitis.

Background: Thymic stromal lymphopoietin (TSLP) and its functional cleavage products are elevated in nasal polyps (NPs) and play important roles in type 2 (T2) inflammation in chronic rhinosinusitis (CRS) with NPs (CRSwNP) by activating myeloid dendritic cells (mDCs) and group 2 innate lymphoid cells (ILC2s). However, whether tezepelumab, a human monoclonal antibody against TSLP, inhibits functional cleaved TSLP and the role of TSLP in CRS without NPs (CRSsNP) have not been studied.

Objective: To investigate the effects of tezepelumab on cleaved TSLP in CRS.

Heterocycles in reactions with boradigermaallyl.

Reactions of boradigermaallyl, which can also be regarded as a chloroborylene stabilzed by two germylene donors, with thiophene, furan, pyridazine and 2,2'-bipyridine are presented. Insertion of the boron atom into the heterocycles is observed and the resulting heterocycles continue to react with the bis(germylene) molecule.

Reproducible image-based profiling with Pycytominer.

Advances in high-throughput microscopy have enabled the rapid acquisition of large numbers of high-content microscopy images. Next, whether by deep learning or classical algorithms, image analysis pipelines commonly produce single-cell features. To process these single cells for downstream applications, we present Pycytominer, a user-friendly, open-source Python package that implements the bioinformatics steps key to image-based profiling.

Factors associated with recurrence in operable breast cancer patients undergoing surgery as the sole treatment modality.

Purpose: Approximately 10% of breast cancer patients with localized operable disease experience recurrence. This study aimed to evaluate patients with early-stage breast cancer (TNM I and II) who underwent surgery without the need for neoadjuvant therapy.

Methods: The total of 117 patients was included in the study: 104 without recurrence and 13 with recurrence.

Impact of a lambda-cyhalothrin formulation residues on larval Apis mellifera: Examining midgut and fat body morphological response to insecticide chronic exposure.

Pollination by honey bees (Apis mellifera) is crucial for maintaining biodiversity and crop yields. However, the widespread use of pesticides may threaten bees' survival by contaminating their resources. Lambda-cyhalothrin, a neurotoxic insecticide commonly used in agricultural pest control, poses particular risks.