Mechanisms involved in the valproic acid-induced hepatotoxicity: A Comprehensive review.

Adverse drug reactions (ADR) remain a challenge in modern healthcare, particularly given the increasing complexity of therapeutics. WHO's definition of an adverse drug reaction as a response to a drug that is noxious and unintended and occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for modification of physiological function. This definition underscores the importance of monitoring and mitigating unintended drug effects, particularly for widely used medications like valproic acid (VPA).

A comparison of CXR-CAD software to radiologists in identifying COVID-19 in individuals evaluated for Sars CoV-2 infection in Malawi and Zambia.

AI based software, including computer aided detection software for chest radiographs (CXR-CAD), was developed during the pandemic to improve COVID-19 case finding and triage. In high burden TB countries, the use of highly portable CXR and computer aided detection software has been adopted more broadly to improve the screening and triage of individuals for TB, but there is little evidence in these settings regarding COVID-19 CAD performance. We performed a multicenter, retrospective cross-over study evaluating CXRs from individuals at risk for COVID-19.

Review of Quality Audit in a Radiation Oncology Department in a Tertiary Care Hospital- 2 Year-Results.

Objectives: This study aimed to report the findings of comprehensive weekly quality audit of radiotherapy procedures conducted at our institute, assessing various domains including clinical notes, contour delineation, treatment planning, prescription accuracy, patient-specific quality assurance, and treatment set-up checks.

Material And Methods: The audit protocol, based on the Peer Review Audit Tool (PRAT) from the Royal Australian and New Zealand College of Radiologists, evaluated six critical parameters: clinical decisions, contours, treatment prescriptions, plan evaluation, plan quality assurance, and daily treatment set-ups. Patients were assessed for changes categorized as no change, minor change, or major change.

The Clinical and Genetic Diversity of Thyroid Hormone Resistance: Four Clinical Vignettes.

Introduction: Resistance to thyroid hormones (RTH) is a rare but important genetic cause of decreased peripheral tissue responses to the actions of thyroxine. Most RTH cases are caused by mutations in thyroid hormone receptor β (TRβ, THRB), while a few are caused by mutations in thyroid hormone receptor α (TRα, THRA). RTH is clinically heterogeneous, and the biochemical features are often confusing, resulting in misdiagnoses, mismanagement, and life-long consequences for affected individuals.