Lymphoangionodulary anastomosis in cancer with metastases in lymph nodes.

The paper presents the research results of lymphoangionodulary anastomosis perfusion properties in breast cancer. We have carried out the detailed study of 100 axillary lymph nodes affected with metastatic breast cancer and removed them using the method of sonolipodestruction ex vivo. The results obtained in the course of the study provide a basis for a new look at the problems of lymphodynamics in metastatic damage of a lymph system.

The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer.

The expression profiling analysis of inflammatory chemokines and their receptors in newly formed lymph nodes in breast cancer was carried out. The analysis revealed the increase in expression of the genes CCL16, XCR1, CYFIP2, TNFSF14 and the reduction in expression of chemokine ligands CXCL5 and CXCL12 in tertiary lymphoid organs. The obtained results allow us to suggest that the process of induction of lymph nodes neogenesis is identical (in its key mechanisms) to the process of lymphoid tissue neogenesis in autoimmune diseases and in some infections, but may have different triggers.

[The dynamics of alteration of liquors' proteins under malignant neoplasms].

The article presents the results of analysis of lymph and blood in 78 patients with breast cancer of I, II. III and IV stages. The content of total protein, albumins, globulins and fibrinogens was detected to study the protein balance in biological liquors under various stages of cancer.

[Morphological peculiarities of the adipose tissue and their significance for the ultrasound lipodestruction].

Using the autopsy material obtained from 20 human corpses, the samples of subcutaneous adipose tissue of the gluteal, abdominal, inguino-ileal and axillar areas, as well as the samples of mesenterial, retroperitoneal, mediastinal, pararectal and paranephral adipose tissue was studied histologically. The average sizes of the lobes and of adipocytes were measured, and the degree of the development of connective tissue elements was determined. Adipose tissue was found to have a similar general structural plan in all the areas studied, however the differences were noted in the thickness of the interlobular connective tissue septae and in tissue vascularization.

[Liposonodestruction in spleen-saving operations in abdominal oncology].

Based on an analysis of morphological investigations the authors have shown distinctions of the adipose tissue in different topographic-anatomical areas of man. It was found that destruction of fat with an apparatus of sonolipodestruction takes different time. This technology was most efficient when used in operations on organs of the abdominal cavity, in mobilization of the spleen.