[Changes in insulin secretion shortly after injury of the ventromedial hypothalamus].

In 8 series of the experiments on 95 rats changes in the immunoreactive insulin (IRI) and blood sugar content, as well as of the indices of insulin deposition in pancreatic islands, were studied 5 hours after the injure to the hypothalamic ventromedial nuclei (HVMN) and subsequent two-hour feeding of the animals. It was found that the blood sugar- and IRI levels are significantly lowered in rats 5 hours after HVMN affection, caused by vigorous emotional and motor excitation. The 2-hour feeding of the animals 5 hours after HVMN disturbance led to an increase in the glycemia and insulinemia (almost 5 times) levels.

[Insulin secretion in rats after hypothalamic damage].

Experiments conducted on female Wistar rats showed that 24 hours after the injury of the ventromedial nuclei of the hypothalamus (VMNH) without animal starvation there occurred a slight reduction of insulin in the islets and a significant elevation of the blood immunoreactive insulin (IRI) level, without any glycemia reduction. In animals with intact VMNH glybenclamide produced no changes in the insulin depot in the pancreatic cells, but somewhat increased the IRI level. However, after the VMNH injury glybenclamide caused a sharp insulin depletion in the islets, and a marked elevation of IRI and a decrease of sugar in the blood.