Publications by authors named "R S Frech"

Objective: We set out to determine whether adding medium chain triglyceride (MCT) oil as a dietary supplement to standard diet in adult subjects with intractable epilepsy in a U.S. neurology clinical practice was associated with a reduction in number of seizures.

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The location of the hydroxyl group in monohydroxy alcohols greatly affects the temperature dependence of the liquid structure due to hydrogen bonding. Temperature-dependent self-diffusion coefficients, fluidity (the inverse of viscosity), dielectric constant, and density have been measured for several 1-alcohols and 3-alcohols with varying alkyl chain lengths. The data are modeled using the compensated Arrhenius formalism (CAF).

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Article Synopsis
  • - The study evaluates the effects of low-dose verapamil (20mg three times a day) as an additional treatment for adults with epilepsy who still experience frequent seizures despite taking multiple anti-seizure medications.
  • - Out of 19 patients who completed the study, over half (53%) experienced significant reductions in seizure frequency, with no participants stopping treatment due to side effects, indicating good tolerability of the low-dose verapamil.
  • - The findings suggest that low-dose verapamil may improve seizure control in treatment-resistant epilepsy, particularly in cases like Lennox-Gastaut syndrome, and future studies with larger populations are recommended for more conclusive results.
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Decades of studying isothermal and temperature-dependent mass and charge transport in polar organic liquids and electrolytes have resulted in two mutually incompatible models and the failure to develop a general molecular level picture. The hydrodynamic model describes conductivity, diffusion, and dielectric relaxation in terms of viscosity, while the inadequacy of the thermal activation model leads to empirical descriptions and fitting procedures whose adjustable parameters have little or no physical significance. We recently demonstrated that transport data can be characterized with a high degree of accuracy and self-consistency using the compensated Arrhenius formalism (CAF), where the transport property of interest assumes an Arrhenius-like form that also includes a dielectric constant dependence in the exponential prefactor.

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Temperature-dependent transport properties in ionic liquids, such as the ionic conductivity and fluidity, are often characterized empirically through equations that require multiple adjustable fitting parameters in order to adequately describe the data. These fitting parameters offer no insight into the molecular-level mechanism of transport. Here the temperature dependence of these transport properties in 1-alkyl-3-methylimidazolium triflate ionic liquids is explained using the compensated Arrhenius formalism (CAF), where the conductivity or fluidity assumes an Arrhenius-like form that also contains a dipole density dependence in the exponential prefactor.

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