Publications by authors named "R S Eisenberg"
Background: The self-expanding, supra-annular Evolut valve is an established platform for Transcatheter Aortic Valve Implantation (TAVI). Evolut PRO introduced an outer sealing wrap to mitigate paravalvular leakage. We evaluated the 3-year clinical outcomes and valve performance of the Evolut PRO in standard clinical practice for severe aortic stenosis (AS) patients at intermediate or higher risk for surgery.
View Article and Find Full Text PDFArticle Synopsis
- Allergic rhinitis (AR) affects 5% to 50% of the population worldwide, but specific studies on sensitization in Israeli patients have been limited.* -
- A study of 1,308 AR patients in Israel revealed an 86% overall positive skin prick test rate, with indoor allergens affecting 76% of participants; the most common allergens identified were mites, olive tree pollen, grass pollen, and cat dander.* -
- The findings can help allergists customize skin prick test panels and improve immunotherapy by focusing on the most prevalent aeroallergens in different climate zones.*
Article Synopsis
- APECED is a serious genetic autoimmune disorder linked to variants in the autoimmune regulator (AIRE) gene, with 16% of evaluated patients lacking known harmful variants, most of whom are of Puerto Rican descent.
- Researchers discovered a deep intronic variant (c.1504-818 G>A) in these patients that causes a cryptic splice site leading to a dysfunctional protein through pseudoexon inclusion.
- They developed an antisense oligonucleotide (ASO) that corrected this genetic issue, demonstrating the potential for targeted treatments in APECED patients.
Article Synopsis
- A study evaluated permanent pacemaker implantation (PPI) rates in patients who underwent transcatheter aortic valve replacement (TAVR) using Evolut valves from July 2018 to June 2021, reporting significant trends in PPI rates over time.
- Out of 54,014 procedures, the 30-day PPI rate dropped from 16.6% in 2018 to 10.8% in 2021, and in-hospital rates decreased by 40.1% during the same period, indicating improved outcomes.
- Key factors associated with a higher likelihood of needing a new PPI included existing conduction defects, atrial fibrillation, use of home
The maximum rate at which animals take up oxygen from their environment (ṀO2,max) is a crucial aspect of their physiology and ecology. In fishes, ṀO2,max is commonly quantified by measuring oxygen uptake either during incremental swimming tests or during recovery from an exhaustive chase. In this Commentary, we compile recent studies that apply both techniques to the same fish and show that the two methods typically yield different mean estimates of ṀO2,max for a group of individuals.
View Article and Find Full Text PDF