Publications by authors named "R S Ebrahim"

A niche in the context of microorganisms defines the specific ecological role or habitat inhabited by microbial species within an ecosystem. For the human commensal Malassezia, the skin surface is considered its primary niche, where it adapts to the skin environment by utilising lipids as its main carbon and energy source. However pathogenic characteristics of Malassezia include the production of allergens, immune modulation and excessive lipid utilisation, which result in several diseases such as pityriasis versicolor, seborrheic dermatitis, Malassezia folliculitis and atopic dermatitis.

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  • Ferritin-based hybrids are large macromolecules with potential uses in drug delivery and vaccines, but their design is complicated.
  • Researchers designed hybrids using ferritin from Helicobacter pylori and a Small Ubiquitin-like Modifier, discovering that their assembly was influenced by varying preparation methods.
  • They developed a quantitative model to analyze how different stoichiometries affected the structure of these hybrids, revealing unexpected patterns and establishing a framework for better design of ferritin-based systems.
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Fresen, an African medicinal plant, is known for its analgesic, antiulcer, and antimicrobial properties, with its leaves, bark, and fruits deeply ingrained in indigenous healing practices. Two lectins, TerBLL (from leaves) and TerBSL (from seeds) of Fresen, were purified using salting-out and affinity chromatography on a fetuin-agarose column. The purified lectins were then assessed for protein yield, hemagglutination activity, and physicochemical properties.

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  • The U-21 strain secretes chaperones, like the ClpL protein, which shows potential as a disaggregase for treating Parkinson's disease.
  • Analysis of the C0965_000195 gene reveals that ClpL can assist in refolding misfolded proteins, particularly luciferases, helping cells manage protein damage.
  • Experiments indicate that both the secreted culture medium from U-21 and purified ClpL can protect proteins from denaturation, suggesting ClpL's key role in the strain’s potential therapeutic benefits.
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Several clades of luminescent bacteria are known currently. They all contain similar lux operons, which include the genes luxA and luxB encoding a heterodimeric luciferase. The aldehyde oxygenation reaction is presumed to be catalyzed primarily by the subunit LuxA, whereas LuxB is required for efficiency and stability of the complex.

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