Memory of chirality in a room temperature flow electrochemical reactor.

Chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of "memory of chirality" has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow.

Memory of Chirality in Flow Electrochemistry: Fast Optimisation with DoE and Online 2D-HPLC.

Amino acid derivatives undergo non-Kolbe electrolysis to afford enantiomerically enriched α-alkoxyamino derivatives through intermediate chiral carbenium ions. The products contain N,O-acetals which are important structural motifs found in bioactive natural products. The reaction is performed in a continuous flow electrochemical reactor coupled to a 2D-HPLC for immediate online analysis.

How good is your lens? Assessing performance with MTF full-field displays.

Modern optical systems achieve incredible resolution and require more thorough testing. We present a method of evaluating and displaying the modulation transfer function (MTF) of a lens over its full rectangular field of view. The method consists of utilizing commercially available MTF test stations to gather data as well as custom software to plot the results.

Opioid guidelines in the management of chronic non-cancer pain.

Background: Opioid abuse has increased at an alarming rate. However, available evidence suggests a wide variance in the use of opioids, as documented by different medical specialties, medical boards, advocacy groups, and the Drug Enforcement Administration (DEA).

Objectives: The objective of these opioid guidelines by the American Society of Interventional Pain Physicians (ASIPP) is to provide guidance for the use of opioids for the treatment of chronic non-cancer pain, to bring consistency in opioid philosophy among the many diverse groups involved, to improve the treatment of chronic non-cancer pain, and to reduce the incidence of drug diversion.