Publications by authors named "R S Baric"
Taekwondo is a weight-classified combat sport. Taekwondo athletes often resort to restrictive eating behaviors and weight reduction, especially just before competitions, which, in the long run, endanger their physical and mental health. This study aimed to determine the incidence of eating disorder (ED) symptoms regarding sex, age, and competitive level categories and examine the correlation and contribution of coach behavior, body satisfaction, and goal orientation to the development of ED symptoms in different subgroups.
View Article and Find Full Text PDFMiddle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus that causes severe respiratory illness in humans. There are no licensed vaccines against MERS-CoV and only a few candidates in phase I clinical trials. Here, we develop MERS-CoV vaccines utilizing a computationally designed protein nanoparticle platform that has generated safe and immunogenic vaccines against various enveloped viruses, including a licensed vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
View Article and Find Full Text PDFArticle Synopsis
- The N-terminal domain (NTD) of the spike protein in coronaviruses like SARS-CoV-2 is not well understood, but some rare antibodies targeting it can neutralize the virus, indicating its potential role in immune protection.
- A specific monoclonal antibody, COV1-65, has been identified that effectively recognizes the NTD of the SARS-CoV spike protein and demonstrated disease prevention in mice when administered before viral exposure.
- The interaction between COV1-65 and the SARS-CoV spike protein reveals key structural details that could inform the development of effective vaccines against various sarbecoviruses.
Article Synopsis
- MERS-CoV is a serious virus with a 36% death rate in humans, and there's currently no vaccine or treatment approved for use in humans or camels.
- Researchers developed special miniproteins that effectively bind to and neutralize various forms of the MERS-CoV spike protein, which is crucial for the virus's ability to infect cells.
- Testing in mice showed that administering one of these miniproteins intranasally can protect against MERS-CoV infection, suggesting potential for further clinical development as a new preventive measure against this virus.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused more than 7 million deaths globally. Despite the presence of infection- and vaccine-induced immunity, SARS-CoV-2 infections remain a major global health concern because of the emergence of SARS-CoV-2 variants that can cause severe acute coronavirus disease 2019 (COVID-19) or enhance Long Covid disease phenotypes. About 5 to 10% of SARS-CoV-2-infected individuals develop Long Covid, which, similar to acute COVID 19, often affects the lung.
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