Publications by authors named "R S Avedian"
Article Synopsis
- The LightFix Trial aimed to assess the effectiveness of the IlluminOss System (IS) in treating impending and completed pathological fractures of the humerus over one year.
- A study with 81 patients showed significant decreases in pain and increases in upper limb function after treatment, with notable improvements in pain scores and functional metrics throughout the year.
- While the IS provided benefits, it had a device fracture rate of 15%, suggesting caution when used alone for completed fractures.
Characterization of the diverse malignant and stromal cell states that make up soft tissue sarcomas and their correlation with patient outcomes has proven difficult using fixed clinical specimens. Here, we employed EcoTyper, a machine-learning framework, to identify the fundamental cell states and cellular ecosystems that make up sarcomas on a large scale using bulk transcriptomes with clinical annotations. We identified and validated 23 sarcoma-specific, transcriptionally defined cell states, many of which were highly prognostic of patient outcomes across independent datasets.
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- The study examined local recurrence patterns in soft tissue sarcoma (STS) patients who underwent surgery with or without radiation therapy (RT) to assess the risks of skin recurrence.
- Out of 206 patients reviewed, only 20 (9.7%) experienced local recurrence, with most of these cases occurring in deep or subcutaneous tissues rather than the skin.
- The findings suggest that skin recurrences were uncommon and primarily associated with tumors that already involved the skin, supporting current guidelines that do not recommend routine use of bolus during RT for STS not involving the skin.
Purpose: Models to study metastatic disease in rare cancers are needed to advance preclinical therapeutics and to gain insight into disease biology. Osteosarcoma is a rare cancer with a complex genomic landscape in which outcomes for patients with metastatic disease are poor. As osteosarcoma genomes are highly heterogeneous, multiple models are needed to fully elucidate key aspects of disease biology and to recapitulate clinically relevant phenotypes.
View Article and Find Full Text PDFObjective: To assess the safety and efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment extra-abdominal desmoids.
Methods: A total of 105 patients with desmoid fibromatosis (79 females, 26 males; 35 ± 14 years) were treated with MRgFUS between 2011 and 2021 in three centers. Total and viable tumors were evaluated per patient at last follow-up after treatment.