The glucogenic capacity of the fetal pig: developmental regulation by cortisol.

In the present study, the ontogenic changes in gluconeogenic enzyme activities and in hepatic glycogen and beta-adrenergic receptor levels were investigated in fetal pigs from 70 days of gestation until delivery at term (114 +/- 2 days). The values were compared with those observed in fetuses infused subcutaneously with cortisol for 6 days beginning at 82-84 or 92-94 days of gestation. Tissue glucose-6-phosphatase (G6Pase) activity increased with increasing gestational age in the liver, kidney and duodenum of control fetal pigs.

Release of glucose from the liver of fetal and postnatal sheep by portal vein infusion of catecholamines or glucagon.

1. The blood flow to the liver in fetuses near term, newborn and adult sheep was measured by the Fick principle, using radionuclide-labelled plastic microspheres, before and during infusion of adrenaline, noradrenaline or glucagon. 2.

Blood flow to and the metabolism of glucose and lactate by the liver in vivo in fetal, newborn and adult sheep.

1. The blood flow to the liver in fetuses near to term, in newborn and in adult sheep was measured in vivo by the Fick principle using radionuclide-labelled plastic microspheres and timed withdrawal of reference organ blood samples. 2.

Effect of dietary nitrogen on urinary excretion of non-protein nitrogen in adolescent sickle cell patients.

The nitrogen economy of sickle cell patients has been found to be FRpaired due to several factors including poor absorption of protein products and higher than normal urinary nitrogen excretion. The increased urinary loss of nitrogen is probably due to increased protein catabolism as a result of inadequate intestinal supply of nitrogen and its poor utilization. The relationship between urinary nitrogen excretion and dietary nitrogen intake was investigated.