Publications by authors named "R Rupesh Bala Murugan"
Verrucae vulgaris are infectious keratotic lesions caused by the human papillomavirus (HPV), frequently impairing an individual's quality of life, mainly when situated on the facial region. Verruca vulgaris constitutes a prevalent dermatological issue with diverse repercussions for those affected. The interaction among HPV, the immune system, and treatment methods requires a sophisticated comprehension of this illness.
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- Processed foods are loaded with food additives that enhance flavor, texture, and shelf life, but many of these additives can act as endocrine-disrupting chemicals (EDCs).
- EDCs can interfere with hormone regulation and cause health issues like obesity, diabetes, and reproductive problems, as well as developmental abnormalities.
- The review seeks to identify harmful food additives, explore their uses in the food industry, and propose strategies for reducing such additives in favor of safer alternatives to safeguard human health.
Article Synopsis
- This systematic review investigates predictors of intradialytic hypotension (IDH) in critically ill patients receiving kidney replacement therapy (KRT) for acute kidney injury (AKI).
- It analyzed data from 8 studies with 2873 patients, finding that machine learning models, particularly Extreme Gradient Boosting Machine (XGB) and deep neural networks (DNN), had the highest predictive accuracy compared to traditional indicators.
- The study emphasizes the need for combining predictive models and clinical indicators to enhance prediction of IDH and highlights that further validation in different healthcare settings is necessary.
Background: Currently licensed and approved malaria subunit vaccines provide modest, short-lived protection against malaria. Immunization with live-attenuated malaria parasites is an alternative vaccination strategy that has potential to improve protection.
Methods: We conducted a double-blind, controlled clinical trial to evaluate the safety, side-effect profile, and efficacy of immunization, by means of mosquito bites, with a second-generation genetically attenuated parasite (GA2) - a single knockout NF54 parasite (sporozoite form) with extended development into the liver stage.
The development of targeted nanotherapeutics has emerged as a pivotal advancement in cancer treatment, aiming to enhance the efficacy and specificity of drug delivery while minimizing systemic toxicity. Due to their biocompatibility and modifiable surface properties, Chitosan-based nanoparticles have shown considerable promise in encapsulating and delivering therapeutic agents directly to tumor sites. This study investigates the potential of 1,5-diary pyrazole derivative (T4)-loaded chitosan (CS) nanoparticles as a novel anticancer agent, evaluating their physical characteristics, in vivo biodistribution, and therapeutic efficacy against cancerous cells.
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