Publications by authors named "R Rubi-Castellanos"
Introduction: Genetic variants that control dopamine have been associated with obesity in children through loss of control of satiety and impulses, the manifestation of addictive eating behaviors, and specific personality traits. The variants include -rs9939609 and the 30 pb u-VNTR low-transcription alleles (LTA).
Objective: To evaluate the genetic association of -rs9939609 and the LTA, along with personality traits and eating behavior with obesity in Mayan children from Mexico.
Objectives: High expression levels (HELs) of microRNA-122 (miR-122) or microRNA-222 (miR-222) have been associated with insulin resistance (IR), which leads to the development of obesity. The association between HELs of circulating miR-122 and miR-222 and the risk of obesity was evaluated in Mexican school-aged children, where childhood obesity is the primary cause of morbidity.
Methods: Anthropometric data, biochemical parameters, and caloric intake were obtained in 50 children with obesity and 49 children with normal weight.
Article Synopsis
- Tamoxifen metabolism varies among individuals, categorized into four genetic phenotypes (gPM, gIM, gNM, gUM), but their connection to tamoxifen side effects (TSE) in Mexican Mestizo patients is not well-known.
- This study involved evaluating 71 women for genetic phenotypes and their relationship to self-reported side effects, finding that hot flashes, arthralgia, headaches, and cramps were common.
- Although none of the genetic phenotypes predicted TSE, factors like contraceptive use and past chemotherapy were found to be significant predictors, highlighting a gap in pharmacogenetic research for Latin-American populations.
Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.
Am J Hum Biol
January 2019
Objectives: Genetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.
Methods: We included 318 school-aged children with obesity or overweight status (body mass index [BMI]: >85th percentile) and 303 children with normal weight (BMI: 15th-85th percentile).