Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats.

Purpose: Hypoxia-inducible factor (HIF) drives transcription of critical hypoxia response genes, increasing the production of red blood cells in low oxygen conditions. In the absence of hypoxia, HIF is degraded by prolyl hydroxylases (HIF-PHs). Pharmacological HIF-PH inhibition stabilizes HIF and is being studied as a treatment for anemia.

The 30th anniversary of the UK Association for Computational Mechanics.

This article commemorates the third decade of the UK Association for Computational Mechanics, formerly known as the Association of Computational Mechanics in Engineering. An historical overview is provided, from the establishment of the Association in March 1992 up to the end of 2022. The article includes brief biographies of the main researchers involved in the establishment of the Association.

Dose-dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study.

Pharmacological magnetic resonance imaging (phMRI) is a noninvasive method used to evaluate neural circuitry involved in the behavioral effects of drugs like ketamine, independent of their specific biochemical mechanism. The study was designed to evaluate the immediate effect of esketamine, the S-isomer of (±) ketamine on brain activity in awake mice using blood oxygenation level dependent (BOLD) imaging. It was hypothesized the prefrontal cortex, hippocampus, and brain areas associated with reward and motivation would show a dose-dependent increase in brain activity.