Publications by authors named "R Roesler"
Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).
Methods: A longitudinal observational retrospective study was conducted.
Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABA) receptor, which is a ligand-gated ion channel. GABA receptor activation via GABA binding allows for an intracellular influx of Cl ions, thus inducing cellular hyperpolarization. Each GABA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer.
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- - Changes in epigenetic processes like histone acetylation are important for the function and progression of pediatric brain tumors, with drugs like valproic acid (VPA) showing potential as anticancer therapies by inhibiting histone deacetylases (HDACs).
- - VPA treatment resulted in reduced viability of medulloblastoma (MB) cells, induced cell cycle arrest, and altered gene expression related to oncogenes and differentiation, alongside morphological changes that suggest neuronal differentiation.
- - The effects of VPA on MB cells included modifications in histone acetylation patterns that correlated with patient outcomes, suggesting its potential to influence clinical prognosis by targeting stemness and differentiation in specific MB subgroups.
Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-ES-1 ES cells and affects the cell cycle.
View Article and Find Full Text PDFChelating ligands have had a tremendous impact in coordination chemistry and catalysis. Notwithstanding their success as strongly σ-donating and π-accepting ligands, to date no chelating bis[cyclic (alkyl)(amino)carbenes] have been reported. Herein, we describe a chelating, C-symmetric bis[cyclic (alkyl)(amino)carbene] ligand, which was isolated as a racemic mixture.
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