Publications by authors named "R Rodriguez-Guzman"
Water deprivation induces a systemic procatabolic state that differentially affects oxidative and glycolytic skeletal muscles in male mice.
João da Cruz-Filho Daniely Messias Costa Tatiane Oliveira Santos Raquel Prado da Silva Hevely Catharine Anjos-Santos
Am J Physiol Regul Integr Comp Physiol
January 2025
Article Synopsis
- Dehydration leads to significant changes in metabolic processes and muscle protein metabolism in mice after 36 hours of water deprivation.
- Mice exhibited signs of dehydration including weight loss and altered hormone activity, along with changes in liver mass and blood chemistry.
- Skeletal muscle showed increased protein breakdown and adaptations in muscle fiber size, indicating that muscle response may vary between different muscle types during dehydration.
Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are the world's leading cause of mortality and morbidity. Endothelial dysfunction involved in CVD pathogenesis is a trigger, or consequence, of oxidative stress and inflammation. Endothelial dysfunction is defined as a diminished production/availability of nitric oxide, with or without an imbalance between endothelium-derived contracting, and relaxing factors associated with a pro-inflammatory and prothrombotic status.
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