Impact of Atopic Dermatitis on Adolescents and Families: A Mixed-Method Systematic Review.

Aims: To summarise the evidence regarding the impact of atopic dermatitis on adolescents and their families as well as their healthcare needs and to propose a nursing care plan based on the findings.

Design: Mixed-method systematic review.

Methods: Twenty-four studies were included, of which 19 were quantitative and 5 were qualitative.

The time dependent influence of curvature and topography of biomaterials in the behavior of corneal endothelial cells.

Among the different layers of the cornea, the corneal endothelium, which is composed of corneal endothelial cells (CEC), plays a key role in the maintenance of cornea transparency. Based on the donor shortages and the limitations associated with transplantation, in this work we have developed collagen hydrogels with different patterned structures on the surface to provide topographies in ranges similar to the natural environment that CEC sense. This aimed at stimulating cells to maintain a typical CEC phenotype and provide alternatives to corneal transplantation.

Metapopulation model of phage therapy of an acute lung infection.

Unlabelled: Infections caused by multidrug resistant (MDR) pathogenic bacteria are a global health threat. Bacteriophages ("phage") are increasingly used as alternative or last-resort therapeutics to treat patients infected by MDR bacteria. However, the therapeutic outcomes of phage therapy may be limited by the emergence of phage resistance during treatment and/or by physical constraints that impede phage-bacteria interactions .

Silica 3D printed scaffolds as pH stimuli-responsive drug release platform.

Silica-based scaffolds are promising in Tissue Engineering by enabling personalized scaffolds, boosting exceptional bioactivity and osteogenic characteristics. Moreover, silica materials are highly tunable, allowing for controlled drug release to enhance tissue regeneration. In this study, we developed a 3D printable silica material with controlled mesoporosity, achieved through the sol-gel reaction of tetraethyl orthosilicate (TEOS) at mild temperatures with the addition of different calcium concentrations.