Publications by authors named "R Rodado"
Key Points: Kidney survival in C3 glomerulopathy is significantly higher in patients with a disease chronicity score <4 and proteinuria <3.5 g/d, regardless of baseline eGFR. A faster eGFR decline in C3 glomerulopathy is associated with higher probability of kidney failure.
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- C3 glomerulopathy is a rare kidney disease that affects how the complement system works, making it hard to predict individual patient outcomes.
- Researchers conducted a study involving 115 patients across 35 nephrology centers to develop a nomogram that forecasts long-term kidney survival using factors like estimated glomerular filtration rate (eGFR), proteinuria, and chronicity score from kidney biopsies.
- The final nomogram showed high accuracy (C-index of 0.860) in predicting kidney failure risk at 1, 2, 5, and 10 years, demonstrating reliable calibration between predicted and actual outcomes.
Article Synopsis
- C3 glomerulopathy associated with monoclonal gammopathy (C3G-MIg) is a rare kidney condition, and this study examined the clinical and histological characteristics of patients diagnosed with it between 1995 and 2021.
- The study involved 23 patients, with a median age of 63 years, and found that a significant number reached kidney failure (39%) during an average follow-up of 40 months, with transplant recipients faring particularly poorly.
- The researchers concluded that the C3G histologic index is useful for predicting kidney prognosis, noting that clone-targeted therapies improved survival rates in patients who responded to treatment.
Article Synopsis
- This study investigates how changes in protein levels in urine (proteinuria) over time relate to kidney health in patients with complement component 3 (C3) glomerulopathy.
- Conducted across 35 nephrology departments in Spain, the research analyzed patient data from 1995 to 2020, focusing on the link between proteinuria trends and kidney failure risk.
- Findings reveal that higher proteinuria levels significantly increase the risk of kidney failure, while a reduction of 50% or more in proteinuria is associated with a decreased risk, highlighting proteinuria changes as useful indicators for predicting kidney outcomes.
Article Synopsis
- - The study investigates C3 glomerulopathy, a kidney disease linked to abnormalities in the complement system, to identify factors influencing treatment outcomes with corticosteroids and mycophenolate mofetil (MMF).
- - Conducted across 35 nephrology departments in Spain, the research analyzed data from 97 patients diagnosed with C3 glomerulopathy or dense deposit disease to evaluate remission rates and kidney survival.
- - Results showed that treatment with corticosteroids plus MMF led to significantly better outcomes (79% remission; 14% kidney failure) compared to other treatments, especially in patients with autoantibody-mediated forms, while those with genetic variants had only partial remissions.