Publications by authors named "R Rizea"
Brain aneurysms, characterized by abnormal bulging in blood vessels, pose significant risks if ruptured, necessitating precise neuroanatomical knowledge and advanced neurosurgical techniques for effective management. This article delves into the intricate neuroanatomy relevant to brain aneurysms, including the vascular structures and critical regions involved. It provides a comprehensive overview of the pathophysiology of aneurysm formation and progression.
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- Glioblastoma is a notably aggressive cancer with a poor response to standard treatments, highlighting the need for improved therapeutic strategies.
- Despite advancements in immunotherapy for other solid tumors, glioblastoma patients have not seen similar benefits, indicating a unique tumor-mediated immune suppression.
- This review analyzes current research on immune checkpoint inhibitors in glioblastoma, including an assessment of clinical trial data to better understand patient responses to these treatments.
Addressing the challenge of drug-resistant epilepsy, our study offers a novel perspective by retrospectively applying the 5-SENSE score, initially created for stereoelectroencephalography (SEEG) planning, to evaluate its predictive value in patients undergoing vagus nerve stimulation (VNS) therapy. We conducted a comprehensive preoperative diagnostic work-up, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT), video-electroencephalogram (video-EEG), and clinical semiology. We then stratified 76 patients into three groups - low, moderate, and high focality - based on the focality of the seizure-onset zone.
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- - This review focuses on amyotrophic lateral sclerosis (ALS), discussing its causes, symptoms, diagnostic methods, and current and potential future treatments, highlighting the impact of genetic and environmental factors.
- - It summarizes recent research on molecular mechanisms involved in ALS, such as protein misfolding and oxidative stress, which could lead to new treatment targets and improved diagnostics.
- - Although existing treatments offer some benefits, there is a pressing need for more effective therapies, like gene and stem cell therapy, with future research aimed at understanding ALS better and enhancing patient care.
The race to find an effective treatment for glioblastoma (GBM) remains a critical topic, because of its high aggressivity and impact on survival and the quality of life. Currently, due to GBM's high heterogeneity, the conventional treatment success rate and response to therapy are relatively low, with a median survival rate of less than 20 months. A new point of view can be provided by the comprehension of the tumor microenvironment (TME) in pursuance of the development of new therapeutic strategies to aim for a longer survival rate with an improved quality of life and longer disease-free interval (DFI).
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