Publications by authors named "R Ripley"
Background: The use of local consolidative therapy (LCT) in patients with oligometastatic non-small cell lung cancer (NSCLC) is rapidly evolving, with a preponderance of data supporting the benefits of such therapeutic approaches incorporating pulmonary resection for appropriately selected candidates. However, practices vary widely institutionally and regionally, and evidence-based guidelines are lacking.
Methods: The Society of Thoracic Surgeons assembled a panel of thoracic surgical oncologists to evaluate and synthesize the available evidence regarding the role of pulmonary resection as LCT.
Objectives: Patients with advanced lung cancer (LC) face significant physical, psychological, and functional challenges, increasing their reliance on caregivers for practical and emotional support. This study evaluates the efficacy of CareSTEPS (Self-Care, Stress management, Symptom management, Effective communication, Problem-solving, and Social support), a 6-week telephone-delivered intervention designed to improve psychological functioning (depression and anxiety symptoms) and reduce caregiver burden among family caregivers of patients with advanced LC.
Methods: In this multisite, open-label, parallel-group randomized controlled trial, 174 caregivers (74.
Article Synopsis
- Immune checkpoint therapy (ICT) has changed the treatment landscape for malignant pleural mesothelioma (MPM), but nearly half of patients do not see benefits, emphasizing the need for predictive biomarkers.
- This study evaluated the prognostic value of serum soluble mesothelin-related peptide (SMRP) and PD-L1 levels in 125 MPM patients undergoing ICT, using statistical analyses to determine their impact on overall survival (OS).
- Results showed that higher pre-ICT SMRP levels are linked to poorer prognosis, with low levels indicating better survival outcomes, suggesting that SMRP could serve as a valuable biomarker for future MPM treatment studies.