Publications by authors named "R Rimondini"
The IgLON family of cell adhesion molecules consists of five members (LSAMP, OPCML, neurotrimin, NEGR1, and IgLON5) discovered as supporters of neuronal development, axon growth and guidance, and synapse formation and maintenance. Tumour suppression properties have recently been emerging based on antiproliferative effects through the modulation of oncogenic pathways. Available evidence endorses a role for non-coding RNAs or microRNAs as relevant controllers of IgLON molecule expression that can impact their critical physiological and pathological roles.
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- Long-term treatment of rheumatoid arthritis with tumor necrosis factor-α inhibitors can show early changes in disease activity that help predict treatment responses later on.
- The study monitored 1,598 patients over 48 months, comparing the effectiveness of original biologics (adalimumab and etanercept) with their biosimilars.
- Results indicate no significant difference in effectiveness between the original drugs and their biosimilars, with all treatments showing reduced disease activity levels that continued for up to 48 months.
In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal fasciculation, neuronal survival and migration, and synapse formation and maintenance. Among CAMs, the IgLON family comprises five members: Opioid Binding Protein/Cell Adhesion Molecule Like (OPCML or OBCAM), Limbic System Associated Membrane Protein (LSAMP), neurotrimin (NTM), Neuronal Growth Regulator 1 (NEGR1), and IgLON5. IgLONs exhibit three N-terminal C2 immunoglobulin domains; several glycosylation sites; and a glycosylphosphatidylinositol anchoring to the membrane.
View Article and Find Full Text PDFCyclin-dependent kinase-like 5 () deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked gene. CDD is characterized by a broad spectrum of clinical manifestations, including early-onset refractory epileptic seizures, intellectual disability, hypotonia, visual disturbances, and autism-like features. The knockout (KO) mouse recapitulates several features of CDD, including autistic-like behavior, impaired learning and memory, and motor stereotypies.
View Article and Find Full Text PDFIntroduction: Impulse control disorders (e.g. pathological gambling, hypersexuality) may develop as adverse reactions to drugs.
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