Publications by authors named "R Rieffel"
The aim of this study was to evaluate the toxicity of tucumã oil nanocapsules from the Amazon region in silver catfish, . Fish were exposed to water treated with different concentrations of tucumã nanocapsules, white, solubilized oil and surfactant vehicles. After three days of exposure, fish were euthanized and liver, gills and brain removed for analysis of the dichlorofluorescein, nitric oxide and PicoGreen® assays.
View Article and Find Full Text PDFHydroalcoholic extract of leaf of Arachis hypogaea L. (Fabaceae) did not induce toxic effects in the repeated-dose toxicity study in rats.
Regul Toxicol Pharmacol
August 2020
Article Synopsis
- Arachis hypogaea L. (peanut) leaves, used for treating insomnia in Asia, were tested for safety and toxicity in a study involving repeated treatment with a hydroalcoholic extract in rats.
- The study found no significant adverse effects on mortality, weight, locomotor activity, or anxiety behavior after administering doses of 100, 300, or 1000 mg/kg over 28 days.
- While some changes were noted in liver and kidney weights and increased total thiols in female rats, overall, the extract did not show toxicity or harmful effects in the test subjects.
is a plant of the Lamiaceae family which is restricted to the Southern region of Brazil. It is popularly used as an insecticide, but knowledge on it is very scarce. This study aimed to determine the chemical markers of extracts obtained via ultrasound-assisted (UAE-EtOH) and supercritical fluid (SFE-CO) extractions.
View Article and Find Full Text PDFProtective effect of nerolidol-loaded in nanospheres against cerebral damage caused by Trypanosoma evansi.
Naunyn Schmiedebergs Arch Pharmacol
July 2018
Trypanosoma evansi is a zoonotic parasite associated with high animal mortality that has gained importance due to its capacity to infect humans. Recently, some evidences have demonstrated that T. evansi infection causes severe genotoxic and cytotoxic damage in brain cells, contributing to the pathogenesis and clinical signs of the disease.
View Article and Find Full Text PDF[Our experience with late sequelae of closed injuries of the kidney].
J Urol Nephrol (Paris)
June 1973