Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.

Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton-sensing GPCR, GPR65, were systematically characterized. The synthetic agonist BTB09089 (BTB) recapitulated many proton-induced signaling events and demonstrated selectivity for GPR65.

Stimulus Rate Effect on Electrocochleogram Components in Adults with High Risk for Noise Exposure.

Background:  Hidden hearing loss (HHL) is a newly described condition that has been associated with hearing thresholds within normal limits and poorer speech-in-noise (SIN) performance. Furthermore, HHL has been associated with an elevated or absent middle ear muscle reflex (MEMR). One of the leading factors causing HHL is exposure to noise, specifically in patients who experience temporary threshold shift.

Infant body composition trajectories differ by in utero exposure to gestational diabetes mellitus: a prospective cohort from birth to 12 months.

Background: Infants exposed to gestational diabetes mellitus (GDM) in utero are known to have higher fat mass (FM) and less fat-free mass (FFM) at birth, but little is known about how their adiposity changes over the first year of life.

Objectives: We identified growth and body composition patterns across the first year and evaluated for differences by GDM exposure status.

Methods: Among 198 infants (52% GDM exposed), growth and body composition with total body electrical conductivity were obtained from birth to 1 y.

Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience.

The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human use. Traditionally, the pain status of laboratory animals has been inferred from evoked nociceptive assays that measure their responses to noxious stimuli.

Weight Loss, Stability, and Low Weight Gain during Pregnancy among Individuals with Obesity: Associations with Adverse Perinatal Outcomes: An Observational Study.

Objective: The safety of weight loss and low weight gain during pregnancy remains unclear. To determine how different patterns of gestational weight gain (GWG), including weight loss, stability, and low GWG relate to perinatal outcomes by prepregnancy obesity class.

Study Design: The study population included 29,408 singleton livebirths among pregnant people with obesity from Kaiser Permanente Northern California (2008-2013).