Publications by authors named "R Richterova"

Article Synopsis
  • Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are crucial for cancer progression, affecting cell invasiveness by degrading the extracellular matrix, but their specific roles in brain tumors are not fully understood.
  • A study using quantitative real-time PCR found eight deregulated genes in glioblastoma patients compared to those with benign meningiomas, highlighting important differences in tumor aggressiveness.
  • Elevated MMP and TIMP protein levels were observed in glioblastoma patients, suggesting these proteins could be key players in gliomagenesis and potential targets for personalized cancer therapies, though further research is needed to confirm the relationship between gene expression and protein levels.
View Article and Find Full Text PDF

Introduction: Dysphagia after anterior cervical discectomy and fusion (ACDF) is a regular complication. The aim of this study was to identify risk factors for incidence and severity of dysphagia after ACDF with zero-profile spacer.

Methods: Incidence and severity of dysphagia was evaluated preoperatively and for time of three years after ACDF (regular outpatient check-ups) ‒ prospective study with 3-years follow-up.

View Article and Find Full Text PDF

Background: Brain tumors are a heterogeneous group of malignancies characterized by inter- and intratumoral heterogeneity. Among them, the most aggressive and, despite advances in medicine, still incurable remains glioblastoma. One of the reasons is the high recurrence rate of the disease and resistance to temozolomide, a golden standard in chemotherapy of brain tumors.

View Article and Find Full Text PDF

Objectives: To identify risk factors for unilateral non-acute subdural hematomas NASH recurrence, as well as to perform volumetric quantitative analysis of hematoma, postoperative pneumocephalus and extent of hematoma evacuation.

Background: Recurrence of NASH increases morbidity and mortality and has negative socio-economic consequences. Its accurate prediction could improve patient specific care.

View Article and Find Full Text PDF

This work analyses the results of research regarding the predisposition of genetic hematological risks associated with secondary polyglobulia. The subjects of the study were selected based on shared laboratory markers and basic clinical symptoms. (Janus Kinase 2) mutation negativity represented the common genetic marker of the subjects in the sample of interest.

View Article and Find Full Text PDF