Pharmacokinetics of cefodizime in the elderly following single and repeated intravenous administration of 1 g.

In an open, crossover study of 12 patients of mean age 74 (range 64-88) who required perioperative prophylactic antibiotic therapy, cefodizime was administered as a single iv infusion of 1 g, and repeated infusions of 1 g twice daily for 4.5 days. Serum and urine concentrations of cefodizime were determined by high performance liquid chromatography.