Publications by authors named "R Rene-Ramirez"
Article Synopsis
- Scientists studied how brain changes in older people could cause problems with thinking and feeling, particularly in those with mild cognitive issues and depression.
- They looked at 12 people with mild cognitive impairment, 24 people with late-life depression, and 26 healthy individuals using brain scans and tests over 2 years.
- The results showed that specific brain activity patterns could help doctors understand and spot early signs of thinking and mood problems that might lead to Alzheimer's disease.
The Locus Coeruleus (LC) is the major source of noradrenergic neurotransmission. Structural alterations in the LC have been observed in neurodegenerative disorders and at-risk individuals, although functional connectivity studies between the LC and other brain areas have not been yet performed in these populations. Patients with late-life major depressive disorder (MDD) are indeed at increased risk for neurodegenerative disorders, and here we investigated LC connectivity in late-life MDD in comparison to individuals with amnestic type mild cognitive impairment (aMCI) and healthy controls (HCs).
View Article and Find Full Text PDFIntroduction: The care of patients with Alzheimer's disease increases the burden and depression of the main caregiver, although the relationship between the two is not clearly defined.
Aims: To explore the factors associated with depressive symptomatology and burden in the main caregiver and to apply a model of structural equations to identify the relationship between them.
Subjects And Methods: The sample consisted of 127 family caregivers of people with Alzheimer's disease, with a follow-up of 24 months.
Objectives: The aims of the study were to identify the clinical characteristics of three groups of caregivers: spouses, live-in adult-child or non-live-in adult-child, and their relation to the degree of perceived burden (Caregiver Burden Interview).
Methods: The sample comprised 275 Alzheimer's disease primary caregivers, with a follow-up of 24 months. Cognitive, functional and behavioural characteristics were evaluated in persons with dementia, whilst sociodemographic data, use of socio-medical resources, physical and mental health and self-perceived burden were assessed in caregivers.
Background: Anosognosia is common in patients with Alzheimer's disease (AD) and it is frequently related to an increase in time of care demand.
Objective: The aim of the study was to examine the effect of anosognosia on the total costs of informal care in patients with AD.
Methods: This was a prospective longitudinal study with community-dwelling AD patients.