Biomarkers.

Background: Imaging and plasma markers are used as key indicators of disease for Alzheimer's disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models for regional tau pathology measured on postmortem brain tissue using multiple ante-mortem AD biomarkers. We focused on hippocampal and parietal regions that were immunostained with AT8 and 2E9 that reflect early and advanced aspects of tangle maturity, respectively.

Biomarkers.

Background: There is increasing need for noninvasive biomarkers of Alzheimer's Disease (AD) neuropathologic change for early detection and intervention through risk-factor modification and disease-modifying therapies. One such biomarker is the prediction of chronological age from routine clinical tests such as an electrocardiogram (EKG) to discriminate between observed biological age from chronological age for healthy aging. Deviation of true age from predicted age has been associated with heart failure, hypertension, and coronary heart disease.

Biomarkers.

Background: The TAR DNA-binding protein of 43 kDa (TDP-43) is linked to hippocampal volume loss and faster rates of hippocampal atrophy in Alzheimer's disease and primary age-related tauopathy (PART). Hence, TDP-43 is becoming an important player in age-related neurodegeneration. To advance our understanding of TDP-43 effect on hippocampus, we conducted an imaging-pathological study to determine which specific hippocampal subfields are affected by TDP-43 in cases of PART.

Biomarkers.

Background: Parkinson's disease and dementia with Lewy bodies are characterized by abnormal iron deposition in the substantia nigra, which can be measured with quantitative susceptibility mapping (QSM) on MRI. However, neuropathologic validation of the increased QSM in the substantia nigra associated with Lewy body disease (LBD) is lacking. We compared substantia nigra QSM on antemortem MRI between patients with and without Lewy-related pathology which was confirmed by autopsy in all cases.

Alzheimer's Imaging Consortium.

Background: Imaging and plasma markers are used as key indicators of disease for Alzheimer's disease (AD) but their usefulness in predicting regional tau pathology is relatively understudied. Our objective was to construct predictive models for regional tau pathology measured on postmortem brain tissue using multiple ante-mortem AD biomarkers. We focused on hippocampal and parietal regions that were immunostained with AT8 and 2E9 that reflect early and advanced aspects of tangle maturity, respectively.