Publications by authors named "R Reggia"
Article Synopsis
- The study examined how complement levels (C3 and C4) change during pregnancies in women with systemic lupus erythematosus (SLE) and how these changes relate to disease flare-ups and complications.
- A total of 246 pregnancies in 172 SLE patients were analyzed, revealing that low C4 levels at preconception were linked to higher risks of disease flares and obstetric issues, with 89% resulting in live births.
- The findings suggest that monitoring C3 and C4 levels, especially their changes during pregnancy, is important for predicting complications and ensuring better care for SLE patients.
The concern about the offspring's health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children.
View Article and Find Full Text PDFObjectives: The aim was to determine whether assisted reproductive technologies (ARTs) confer additional risk in rheumatic patients (in terms of disease flare and fetal-maternal complications) and whether, if performed, their efficacy is affected by maternal disease.
Methods: Sixty infertile rheumatic women undergoing 111 ART cycles were included. Clinical pregnancy rate, live birth rate, maternal disease flares and maternal-fetal complications were recorded.
Belimumab is a monoclonal antibody against soluble BLyS used for treatment of refractory Systemic Lupus Erythematosus (SLE). Although B cells are the main target of this therapy, a BLyS-dependent T cell activation pathway has also been demonstrated. The aim of the study is to analyze B and T cells phenotype modifications in a cohort of SLE patients treated with belimumab in correlation with serum BLyS levels.
View Article and Find Full Text PDFArticle Synopsis
- * A survey was conducted with 477 women aged 18-55, revealing that many desire larger families than they feel able to have due to health concerns.
- * Improved physician-patient communication is essential, as those who received counseling had better knowledge about their reproductive options, highlighting significant unmet needs.