Publications by authors named "R Ratnasabapathy"
Therapy-related acute lymphoblastic leukemia (t-ALL) is a rare potential complication of chemotherapy. We describe the case of a 47-year-old male patient who was originally diagnosed with t(8;21) positive acute myeloid leukemia (AML) in 2019, received chemotherapy, achieved remission, and was disease-free for the next two years. During a routine follow-up in 2022, he was found to have developed subclinical pancytopenia, and further studies indicated a diagnosis of pH-negative, near-tetraploid B-cell acute lymphoblastic leukemia (B-ALL) that was positive for a Tier 1 TP53 mutation, consistent with t-ALL.
View Article and Find Full Text PDFContext: Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.
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- Glucokinase (GK) is found in the hypothalamic paraventricular nucleus (PVN) and plays a key role in glucose regulation, though its specific function was previously unclear.
- The study reveals that GK in the PVN is part of a glucose-sensing mechanism that controls the release of glucagon-like peptide 1 (GLP-1), which is important for maintaining glucose homeostasis.
- Enhancing GK expression or introducing glucose to the PVN boosts GLP-1 release in response to oral glucose, while reducing GK expression or using nonmetabolizable glucose inhibits this release, highlighting the critical role of GK neurons in glucose response.
Objective: Obesity is a major cause of morbidity and mortality. Few weight-reducing medications are available, and these have limited efficacy. Cushing's Syndrome (caused by elevated glucocorticoid levels) and obesity have similar metabolic features.
View Article and Find Full Text PDFContext: Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans.
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