Development and Characterization of a 13-Plex Binding Assay to Detect Antibodies in Human Samples.

is the leading bacterial cause of diarrhea worldwide, with increasing levels of antibiotic resistance. The greatest burden is among children aged <5 years in low- and middle-income countries, and efforts are ongoing to develop vaccines against this pathogen. One of the challenges associated with the development of a vaccine against is the need for a multivalent vaccine covering the most prevalent serotypes.

Scientists' call to action: Microbes, planetary health, and the Sustainable Development Goals.

Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving the United Nations Sustainable Development Goals (SDGs), highlighting recent and emerging advances in microbial research and technology that can facilitate our transition toward a sustainable future. Given the central role of microorganisms in the biochemical processing of elements, synthesizing new materials, supporting human health, and facilitating life in managed and natural landscapes, microbial research and technologies are directly or indirectly relevant for achieving each of the SDGs.

Transforming vaccinology.

The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Kariko and Drew Weissman for their seminal contributions to the development of mRNA vaccines. Here, we provide a historic perspective on the key innovations that led to the development of some 27 licensed vaccines over the past two centuries and recent advances that promise to transform vaccines in the future.

Next generation of "magic bullets", solutions from the microbial pangenome.

Identification of a toxic agent that—like a sniper—would be capable of targeting pathogenic bacteria and effectively discriminating between “good” and “evil” cells has long been the holy grail of drug discovery. The theory of magic bullet, first pioneered by Paul Ehrlich in the early 1900, has represented since then a “ in immunological research against infectious diseases. Salvarsan, the first arsenic-based drug against syphilis, was the first example showing that this concept was in fact a realistic goal.