Aqueous and serum interferon gamma, interleukin (IL) 2, IL-4, and IL-10 in patients with uveitis.

Objective: To determine the cytokine profile in aqueous humor and peripheral blood from patients with uveitis.

Methods: Cytokines (interferon [IFN]-gamma, interleukin [IL] 2, IL-4, and IL-10) were measured in aqueous humor and peripheral blood samples from 23 patients with uveitis and 16 patients undergoing operation for uncomplicated cataracts (control group) by means of an enzyme-linked immunosorbent assay.

Results: Aqueous and serum samples from patients with uveitis showed higher levels of IFN-gamma and IL-2 than those of controls (P<.

Levels of soluble ICAM-1 and soluble IL-2R in the serum and aqueous humor of uveitis patients.

Purpose: To study the ocular and systemic behaviour of the immune activation markers soluble ICAM-1 and soluble IL-2R in patients with active uveitis.

Methods: We determined the levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood of 23 patients with active uveitis and 16 age and gender matched controls (who were to undergo cataract extraction) by means of ELISA enzyme immunoanalysis.

Results: Patients with uveitis presented higher levels of soluble ICAM-1 and soluble IL-2R in the aqueous humor and peripheral blood.