Publications by authors named "R Rahimian"
Marfan syndrome (MFS) is a systemic connective tissue disorder stemming from mutations in the gene encoding Fibrillin-1 (Fbn1), a key extracellular matrix glycoprotein. This condition manifests with various clinical features, the most critical of which is the formation of aortic root aneurysms. Reduced nitric oxide (NO) production due to diminished endothelial nitric oxide synthase (eNOS) activity has been linked to MFS aortic aneurysm pathology.
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- A novel radiotracer, [C]SL25.1188, targets monoamine oxidase-B (MAO-B) enzyme primarily in astrocytes, linking its levels to altered astrocyte functions observed in schizophrenia.
- A PET scan study involving 38 participants (14 with first-episode psychosis, 7 at clinical high risk, and 17 healthy volunteers) measured MAO-B concentration and found significantly lower levels in the high-risk group compared to healthy individuals.
- The study also revealed that cannabis use impacted MAO-B levels, with a greater reduction in MAO-B concentration found in individuals using cannabis, emphasizing the potential role of astrocyte dysfunction in early psychosis and high-risk states.
Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 diabetes (T2D) in an established monogenic model of obesity-induced T2D, Zucker Diabetic Fatty (ZDF) rats. Acetylcholine (ACh) responses were assessed in phenylephrine pre-contracted rings before and after apocynin, a NADPH oxidase (NOX) inhibitor.
View Article and Find Full Text PDFBackground: Adult hippocampal neurogenesis has been extensively characterized in rodent models, but its existence in humans remains controversial. We sought to assess the phenomenon in postmortem human hippocampal samples by combining spatial transcriptomics and multiplexed fluorescent in situ hybridization.
Methods: We computationally examined the spatial expression of various canonical neurogenesis markers in postmortem dentate gyrus (DG) sections from young and middle-aged sudden-death males.