Publications by authors named "R Rahban"
Objectives: To investigate the association between mobile phone exposure and semen parameters.
Design: A nationwide cross-sectional study.
Setting: Andrology laboratories in close proximity to 6 army recruitment centers.
The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca concentration ([Ca]) and plays an essential role in sperm function. It is mainly activated by the steroid progesterone (P4) but is also promiscuously activated by a wide range of synthetic and physiological compounds. These compounds include diverse steroids whose action on the channel is so far still controversial.
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- A significant decline in sperm count has been noted over the past few decades, particularly in developed regions, prompting researchers to explore the role of seminal fluid composition using metabolomics.
- The research aimed to connect the metabolomic profiles of young healthy men to their semen quality by analyzing samples from a large cohort.
- Findings revealed that specific metabolites linked to sexual development and function can differentiate between men with low and high sperm counts, showcasing untargeted metabolomics as a valuable method to understand male fertility issues.
Background: While cannabis is the most widely used recreational drug in the world, the effects of phytocannabinoids on semen parameters and reproductive hormones remain controversial. Cannabinoid receptors are activated by these compounds at each level of the hypothalamus-pituitary-gonadotropic axis.
Objectives: To assess the impact of the consumption of Δ-9-tetrahydrocannabinol and cannabidiol on semen parameters, as well as on male reproductive hormone and endocannabinoid levels, in a cohort of young Swiss men.
Study Question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?
Summary Answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro.