Publications by authors named "R Racz"
Article Synopsis
- Drug-induced cardiotoxicity is a major reason why drug candidates fail during development, making its evaluation critical in drug testing and regulatory review.
- The study analyzed FDA postmarket adverse events for 2002 drugs, categorizing cardiac toxicity-related terms into 12 relevant groups to create training sets for model development.
- Researchers used two commercial QSAR platforms to develop 12 predictive models, achieving up to 80% sensitivity and negative predictivity, which can improve the screening of potential cardiotoxic drugs in the development process.
The effectiveness of acyclovir, a selective anti-herpesvirus agent, was tested both in silico and in vitro against two ranaviruses, namely the European catfish virus (ECV) and Frog virus 3 (FV3). ECV can cause significant losses in catfish aquaculture, while FV3 poses a risk to vulnerable amphibian populations. The genome of ranaviruses encodes thymidine kinases (TKs) similar to those of herpesviruses.
View Article and Find Full Text PDFAQUILA: A laboratory facility for the irradiation of astrochemical ice analogs by keV ions.
Rev Sci Instrum
September 2024
The detection of various molecular species, including complex organic molecules relevant to biochemical and geochemical processes, in astronomical settings, such as the interstellar medium or the outer solar system, has led to the increased need for a better understanding of the chemistry occurring in these cold regions of space. In this context, the chemistry of ices prepared and processed at cryogenic temperatures has proven to be of particular interest due to the fact that many interstellar molecules are believed to originate within the icy mantles adsorbed on nano- and micro-scale dust particles. The chemistry leading to the formation of such molecules may be initiated by ionizing radiation in the form of galactic cosmic rays or stellar winds, and thus, there has been an increased interest in commissioning experimental setups capable of simulating and better characterizing this solid-phase radiation astrochemistry.
View Article and Find Full Text PDFThe exact mechanism by which diabetic neuropathy develops is still not fully known, despite our advances in medical knowledge. Progressing neuropathy may occur with a persistently favorable metabolic status in some patients with diabetes mellitus, while, in others, though seldom, a persistently unfavorable metabolic status is not associated with significant neuropathy. This might be significantly due to genetic differences.
View Article and Find Full Text PDFA systematic mid-infrared spectroscopic study of thermally processed HS ices.
Spectrochim Acta A Mol Biomol Spectrosc
October 2024
Article Synopsis
- The identification of molecular components in interstellar icy grain mantles relies on comparing laboratory-generated mid-infrared absorption spectra with data from telescopes.
- Despite its significance in astrochemical processes, the molecule HS has not been detected in interstellar ices, even though it's relatively abundant in cometary ices.
- This paper details an extensive study on the mid-infrared spectroscopic characterization of HS ices at various temperatures, aiming to aid in the detection of HS in interstellar environments and icy bodies within the outer Solar System.