Publications by authors named "R R Schimmer"
Article Synopsis
- A study examined the effects of vitamin D3, omega-3s, and a home-based exercise program (SHEP) on bone mineral density (BMD) in healthy older adults aged 70 and above over three years.
- Results showed no significant benefits from omega-3s or SHEP, but vitamin D3 improved total hip BMD and lumbar spine BMD in men with modest gains.
- While there were some positive effects of vitamin D treatment, the overall clinical significance of these findings remains uncertain.
TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic option for TP53-mutant AML/MDS. However, the impact of TP53 deficiency in AML cells on the efficacy of CAR T-cells is unknown.
View Article and Find Full Text PDFBackground: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet may slow cognitive decline in older adults. A potential mechanism could be possible anti-inflammatory properties of the MIND-diet.
Objective: To examine whether adherence to the MIND diet at baseline is associated with the odds of mild cognitive impairment (MCI) and changes in biomarkers of inflammation (High-sensitivity C-reactive Protein(hsCRP), interleukin-6(IL-6)) over three years in adults ≥70 years.
Article Synopsis
- * Caplacizumab, a new treatment that targets von Willebrand factor, isn't approved for use in pregnant or breastfeeding women but shows promise.
- * A case report demonstrates successful off-label use of caplacizumab during a patient's pregnancy, leading to positive outcomes without major complications.
In the past, our research group was able to successfully remove circulating tumor cells with magnetic nanoparticles. While these cancer cells are typically present in low numbers, we hypothesized that magnetic nanoparticles, besides catching single cells, are also capable of eliminating a large number of tumor cells from the blood ex vivo. This approach was tested in a small pilot study in blood samples of patients suffering from chronic lymphocytic leukemia (CLL), a mature B-cell neoplasm.
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