Global meta-analysis shows action is needed to halt genetic diversity loss.

Mitigating loss of genetic diversity is a major global biodiversity challenge. To meet recent international commitments to maintain genetic diversity within species, we need to understand relationships between threats, conservation management and genetic diversity change. Here we conduct a global analysis of genetic diversity change via meta-analysis of all available temporal measures of genetic diversity from more than three decades of research.

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion.

Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have "intergenomic signaling" pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount of mtDNA in mammalian cells remain poorly understood.

Novel candidate genes and genetic basis analysis of kernel starch content in tropical maize.

Background: Starch is the most abundant carbohydrate in maize grains, serving as a primary energy source for both humans and animals, and playing a crucial role in various industrial applications. Increasing the starch content of maize grains is beneficial for improving the grain yield and quality. To gain insight into the genetic basis of starch content in maize kernels, a multiparent population (MPP) was constructed and evaluated for starch content in three different environments.

Exploring the interface of religion, infertility and assisted reproduction: experiences of Pacific Christian adults in Aotearoa New Zealand.

Religion contributes to the identity, well-being, and life satisfaction of many people globally, however, its traditional stance on infertility and assisted reproductive technologies (ART) can conflict with individuals' personal reproductive aspirations and desire for a family. As the fertility rates of certain ethnic and religious groups decline, it is essential to discuss the interface between religion, infertility and ART, to understand how to best navigate the infertility journeys of proclaimed Christians. This article contextualises this discussion in the experiences of eight Pacific Christian adults living with infertility and/or accessing ART in Aotearoa New Zealand.

International Expert-Based Consensus Definition, Classification Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study.

Purpose: Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 classification systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ.