Publications by authors named "R R Regal"
Prescription Produce Programs (PPPs) are increasingly being used to address food insecurity and healthy diets. Yet, limited evidence exists on the effectiveness of integrating lifestyle counseling within a PPP to promote dietary and health behaviors. To describe the implementation of a 6- or 12-week PPP integrating lifestyle counseling to low-income adults.
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- The liver plays a crucial role in how medications are absorbed and metabolized, meaning that dosing and monitoring for patients with cirrhosis must be carefully managed to prevent drug toxicity.
- A review of literature revealed that cirrhosis patients experience decreased first-pass metabolism and altered drug elimination, leading to higher drug exposure levels than the general population.
- The article aims to guide clinicians on how to adjust pain management medications for cirrhosis patients, highlighting the inconsistency of FDA dosing guidelines with recent pharmacokinetic findings.
Introduction: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.
Methods: Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate.
Background: Methylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication. Variability in response and occurrence of adverse events with methylphenidate use may be due to several factors, including drug-drug interactions as well as pharmacogenetic differences resulting in pharmacokinetic and/or pharmacodynamic variances within the general population.
View Article and Find Full Text PDFPreeclampsia is a pregnancy-specific complication with long-term negative outcomes for offspring, including increased susceptibility to type 2 diabetes (T2D) in adulthood. In a rat reduced uteroplacental perfusion pressure (RUPP) model of chronic placental ischemia, maternal hypertension in conjunction with intrauterine growth restriction mimicked aspects of preeclampsia and resulted in female embryonic day 19 (e19) offspring with reduced β-cell area and increased β-cell apoptosis compared with offspring of sham pregnancies. Decreased pancreatic β-cell area persisted to postnatal day 13 (PD13) in females and could influence whether T2D developed in adulthood.
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