Publications by authors named "R R Pindzola"
Xenon-enhanced computed tomography cerebral blood flow measurements in acute cerebral ischemia: Review of 56 cases.
J Stroke Cerebrovasc Dis
October 2012
Objective: Ischemic stroke must be diagnosed promptly if patients are to be treated with thrombolytic therapy. The diagnosis of acute cerebral ischemia, however, is usually based on clinical and computed tomography (CT) scan findings. CT scans are often normal in the first few hours after stroke.
View Article and Find Full Text PDFThe effect of reperfusion therapy on cerebral blood flow in acute stroke.
J Stroke Cerebrovasc Dis
October 2012
The effect of reperfusion therapy on cerebral blood flow (CBF) in acute cerebral ischemia was studied using xenon-enhanced computed tomography (XeCT). The XeCT CBF studies of 10 patients were evaluated before and after thrombolytic therapy. CBF evidence of reperfusion was evaluated in relation to the angiographic results and the clinical outcomes.
View Article and Find Full Text PDFBackground And Purpose: Hemodynamic compromise in symptomatic patients with occlusive vascular disease (OVD) identified by cerebrovascular reserve (CVR) and oxygen extraction fraction (OEF) is an independent predictor of high stroke risk. However, up to 60% of patients compromised by CVR have normal OEF indicating a high rate of discordance. CVR is measured with an acetazolamide challenge, and OEF reactivity (OEFR) to acetazolamide, ie, a hemodynamic challenge, may reveal hemodynamic compromise and less discordance with measurements of CVR.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to identify stroke risk in patients with occlusive vascular disease by measuring oxygen extraction fraction (OEF) and cerebrovascular reserve (CVR).
- Many areas with compromised CVR aren't detected by OEF measurements, prompting researchers to evaluate oxygen extraction fraction response (OEFR) after administering acetazolamide.
- The findings revealed that positive OEFR could indicate hemodynamic compromise in areas with normal OEF, highlighting a correlation between OEFR and CVR in identifying at-risk brain regions.
Article Synopsis
- The study investigates the relationship between oxygen extraction fraction (OEF) and cerebrovascular reserve (CVR) in patients with carotid occlusion, noting discrepancies between regional and hemispheric assessments.
- The research involved measuring OEF and CVR in specific brain regions of 12 patients, highlighting how regional analysis decreased the discordance found in broader hemispheric comparisons.
- The findings suggest that while regional CVR can effectively identify areas with high OEF, further investigation is needed to assess the stroke risk associated with areas showing compromised CVR yet normal OEF.