One-step antifouling coating of polystyrene using engineered polypeptides.

Unwanted nonspecific adsorption caused by biomolecules influences the lifetime of biomedical devices and the sensing performance of biosensors. Previously, we have designed B-M-E triblock proteins that rapidly assemble on inorganic surfaces (gold and silica) and render those surfaces antifouling. The B-M-E triblock proteins have a surface-binding domain B, a multimerization domain M and an antifouling domain E.

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors.

H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of hosts in diverse climatic environments. Fortunately, transmission to and between humans is scarce.

Early intervention in psychosis programs in Africa, Asia and Latin America; challenges and recommendations.

Background: While early intervention in psychosis (EIP) programs have been increasingly implemented across the globe, many initiatives from Africa, Asia and Latin America are not widely known. The aims of the current review are (a) to describe population-based and small-scale, single-site EIP programs in Africa, Asia and Latin America, (b) to examine the variability between programs located in low-and-middle income (LMIC) and high-income countries in similar regions and (c) to outline some of the challenges and provide recommendations to overcome existing obstacles.

Methods: EIP programs in Africa, Asia and Latin America were identified through experts from the different target regions.

"Just-in-time" but a bit delayed: Personalizing digital nudges for healthier online food choices.

As food choices are increasingly made in contexts such as online supermarkets, nudging has been extrapolated to the digital sphere. Digitalization poses unique opportunities to enhance the promotion of healthier food choices online: Digital nudges can be delivered "just-in-time" (JIT), in response to the initial selection of an unhealthy product. Furthermore, digital JIT nudges can be personalized to match user characteristics of behavioral relevance, such as one's food and cognitive processing preferences.

Duration of Antibiotic Treatment for Foot Osteomyelitis in People with Diabetes.

The optimal antimicrobial treatment duration for diabetes-related foot osteomyelitis (DFO) currently needs to be determined. We systematically reviewed the effects of short and long treatment durations on outcomes of DFO. We performed a systematic review searching Cochrane, CENTRAL, MEDLINE, Embase, and CINAHL Plus from inception up to 19 January 2024.