Isolation of a herpes simplex virus type 1-like agent from the brain of a mountain agile gibbon (Hylobates agilis agilis) with encephalitis.

A captive-born 2-yr-old male mountain agile gibbon (Hylobates agilis agilis) that died of encephalitis harbored a herpes simplex virus type 1 (HSV1)-like agent in the brain. A complete necropsy revealed intensive meningeal congestion with nonsuppurative encephalitis. The virus was recovered from frozen brain tissue in Vero cells.

PCR Identification and Differentiation of Baboon Cytomegalovirus From Other Human and Nonhuman Primate Cytomegalovirus.

Background: Differential identification of baboon alpha, beta, and gamma herpesviruses is an essential technology in order to monitor xenozoonotic transmission of baboon viruses to foreign species organ and/or cell recipients. We present polymerase chain reaction techniques that will differentiate known baboon cytomegaloviruses (CMV) from their closely related counterparts found in humans. Methods and Results: Polymerase chain reaction techniques for identification of the known beta herpesviruses commonly present in the baboon are reported.

Myeloencephalitis associated with a viridans group Streptococcus in a colony of Japanese macaques (Macaca fuscata).

Five weaned immature Japanese macaques (Macaca fuscata), bred in captivity, showed nervous signs over a 12-month period. Hemorrhagic cerebral infarcts with vasculitis were detected in four necropsied animals. The distribution and nature of the lesions were consistent with bacterial embolism, and a Streptococcus isolate, biochemically similar to S.

Characterization of a novel syncytium-inducing baboon reovirus.

A syncytium-inducing reovirus was recently isolated from brain homogenates of a baboon suffering from acute, progressive meningoencephalo myelitis. This baboon reovirus (BRV) was classified as a member of the genus Orthoreovirus, family Reoviridae, on the basis of the characteristic capsid morphology and genome and protein profiles. We have assessed the relationship between BRV and the other syncytium-inducing reoviruses in order to determine whether the emergence of this virus represents a host range or pathogenic alteration in a previously described isolate or the appearance of a novel entity.

Sickle cell disease with complicated influenza B virus infection.

The Committee on Infectious Diseases of the American Academy of Pediatrics, and the Advisory Committee on Immunization Practices of the Center for Disease Control for many years have recommended the routine use of influenza vaccine in various hemoglobinopathies including sickle cell disease. This recommendation, however, has not been included in the patient care protocols of the Comprehensive Sickle Cell Centers program of NIHLB. Most clinicians have not used yearly influenza vaccine for their patients with sickle cell disease.