Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures.

Background: We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV) treatment, in primary sclerosing cholangitis associated inflammatory bowel disease (PSC-IBD); NCT05376228.

Method: Fifteen patients with PSC and active colitis (median faecal calprotectin 459µg/g; median total Mayo score 5) were treated with OV (125mg QID) for 4 weeks and followed-up for a further 4 weeks of treatment withdrawal (8 weeks, end-of-study). Colonic biopsies were obtained at baseline and week 4.

Differential development of antibiotic resistance and virulence between species.

Unlabelled: The two species that account for most cases of -associated bacteremia in the United Kingdom are , often a commensal but also an emerging pathogen, and , a well-known antibiotic-resistant species. While these species both cause similar types of human infection and occupy the same niche, (unlike ) has thus far remained susceptible to antibiotics. Comparatively little is known about the biology of , and this is the largest study on it conducted to date, providing valuable insights into its behaviour and potential threat to human health.

Differences in the gut microbiota between Gurkhas and soldiers of British origin.

Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army.

Uncovering a mammalian neural-specific poly(A) binding protein with unique properties.

The mRNA 3' poly(A) tail plays a critical role in regulating both mRNA translation and turnover. It is bound by the cytoplasmic poly(A) binding protein (PABPC), an evolutionarily conserved protein that can interact with translation factors and mRNA decay machineries to regulate gene expression. Mammalian PABPC1, the prototypical PABPC, is expressed in most tissues and interacts with eukaryotic translation initiation factor 4G (eIF4G) to stimulate translation in specific contexts.

Methodological innovations within the RAWES framework for use in development scenarios.

Built development changes the nature of land and its ecosystems, with diverse ramifications for human well-being and the resilience of the socioecological system. Robust and replicable approaches are required to assess ecosystem services generated by sites both predevelopment and for evaluation of postdevelopment options, to assess change and to support a paradigm shift from a "do less harm" to a "regenerative" approach. The Rapid Assessment of Wetland Ecosystem Services (RAWES) approach provides an internationally recognized methodology for systemic assessment of the ecosystem services generated by a site, taking account of all ecosystem services and service categories across multiple spatial scales.