Publications by authors named "R R Lonser"
Convection-enhanced delivery for central nervous system gene therapy is an emerging treatment strategy to modify the course of previously untreatable or inadequately treated neurologic conditions, including brain tumors, metabolic disorders, epilepsy, and neurodegenerative disorders. Ongoing nervous system gene therapy clinical trials highlight advantages and ongoing challenges to this therapeutic paradigm.
View Article and Find Full Text PDFBackground: von Hippel-Lindau disease (VHL) is an autosomal dominant familial neoplasia syndrome. The most common manifestation of VHL is central nervous system hemangioblastomas. VHL patients will often develop multiple hemangioblastomas along their craniospinal axis over their lifetime.
View Article and Find Full Text PDFHistory of biological, mechanistic, and clinical understanding of concussion.
Neurosurg Focus
July 2024
Article Synopsis
- The text traces the historical development of understanding concussions, starting from their first description in the 10th century to modern insights about their long-term effects.
- It highlights the pivotal work of Dr. Harrison Martland in 1928, who linked repeated head injuries in boxers to the development of chronic symptoms, coining the term "punch drunk."
- The authors emphasize the need for further research on preventive and therapeutic measures for concussions, particularly due to the risks associated with chronic traumatic encephalopathy in athletes and military personnel.