Association of Menopause With Functional Outcomes and Disease Biomarkers in Women With Multiple Sclerosis.

Background And Objective: The impact of menopause on the brain is not well understood. Hormonal changes, including puberty and pregnancy, influence the onset and course of multiple sclerosis (MS). After menopause, a worsening of MS disease trajectory measured on the clinician-rated Expanded Disability Status Scale (EDSS) was reported in some, but not all, studies.

Dataset for computational and experimental buckling analysis of constant-stiffness and variable-stiffness composite cylinders.

This dataset encapsulates comprehensive information and experimental outcomes derived from the buckling test of variable-stiffness composite cylinders subjected to axial compression. It is the first dataset about the correlation between experimental and computational analysis for a Rapid-Tow Sheared composite cylinder, a recently developed advanced composite manufacturing technique. The data gathered during the test contains: raw test data for force, end-compression and strain gauges; and digital image correlation.

Photoactivatable Xanthone (PaX) Dyes Enable Quantitative, Dual Color, and Live-Cell MINFLUX Nanoscopy.

The single-molecule localization concept MINFLUX has triggered a reevaluation of the features of fluorophores for attaining nanometer-scale resolution. MINFLUX nanoscopy benefits from temporally controlled fluorescence ("on"/"off") photoswitching. Combined with an irreversible switching behavior, the localization process is expected to turn highly efficient and quantitative data analysis simple.

Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations.

Recently, biologists have gained access to several far-field fluorescence nanoscopy (FN) technologies that allow the observation of cellular components with ~20 nm resolution. FN is revolutionizing cell biology by enabling the visualization of previously inaccessible subcellular details. While technological advances in microscopy are critical to the field, optimal sample preparation and labeling are equally important and often overlooked in FN experiments.