[ENZYME THERAPY OF POSTCHOLECYSTECTOMY SYNDROME IN CHILDREN].

The article provides pathogenetic justification of the need and the effectiveness of enzyme replacement therapy (ERT) of postcholecystectomy syndrome (PHES) in children. Special focus will be on the possibility of using the ERT in PHES in children of different age groups. Personal experience with these drugs in children with cholelithiasis is provided, considering their mechanism of action and side effects of ERT.

[Risk factors and mechanisms of the postcholecystectomy syndrome development in children].

Cholelithiasis has long ceased to be casuistry in childhood. In connection with the steady tendency for it to grow, it has increased the number of surgical interventions on the occasion of holelitiazis. The removal of the gall bladder in some patients is accompanied by disorders on the part of the digestive system, identified as postcholecystectomical syndrome.

[Clinique--pathogenetic features of postcholecystectomy syndrome in children].

Unlabelled: Years of experience observing children with GSD made possible to determine the clinical course and to clarify some of mechanisms of postcholecystectomical syndrome formation in children. Material and methods. There were observed 148 children who underwent cholecystectomy at the age of 3 to 15 years.

Formation of ketols from linolenic acid 13-hydroperoxide via allene oxide. Evidence for two distinct mechanisms of allene oxide hydrolysis.

Incubations of [1-14C]13-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) with hydroperoxide dehydrase preparations from flax seeds lead to the formation of a novel ketol 2 along with the previously known 12-oxo-13-hydroxy-9(Z),15(Z)-octadecadienoic (12,13-alpha-ketol) and 9-hydroxy-12-oxo-10(E),15(Z)-octadecadienoic (gamma-ketol) acids. Compound 2 was identified as 11-hydroxy-12-oxo-9(Z),15(Z)-octadecadienoic acid (11,12-alpha-ketol) in accordance with the data of ultraviolet, mass (chemical ionization and electron impact) and 1H-NMR spectra. During long-term (30 min) incubations the yields of gamma-ketol and 11,12-alpha-ketol increased markedly and the yield of 12,13-alpha-ketol decreased in response to the pH change from basic (pH 7.

Hydroperoxides of alpha-ketols. Novel products of the plant lipoxygenase pathway.

Metabolism of [1-14C]linolenic acid, 13-hydroperoxy-8(Z),11(E),15(Z)-[1-14C]octadecatrienoic acid (13-HPOT) and 9-hydroperoxy-10(E),12(Z),15(Z)-[1-14C]octadecatrienoic acid (9-HPOT) was studied by enzyme preparations from flax, wheat and corn seeds, containing two enzymes of fatty acid metabolism, namely, lipoxygenase and hydroperoxide dehydrase. Along with the previously known products of the hydroperoxide dehydrase pathway, the radiolabel was incorporated into some more polar metabolites. These polar products 1 and 4, formed from 13-HPOT and 9-HPOT, respectively, were purified by reversed-phase and normal-phase HPLC, and investigated by ultraviolet spectroscopy, chemical-ionization and electron-impact mass spectrometry, and 1H-NMR.