Publications by authors named "R R Krueger"
Article Synopsis
- A team of over 180 researchers from more than 40 countries is addressing the issues related to "phantom agents," which are proposed pathogenic agents that are listed without concrete evidence of their existence.
- These phantom agents, identified only through symptoms and lacking proper isolates or genetic data, create obstacles for trade and plant certification, making effective detection and risk assessment difficult.
- The researchers recommend removing these agents from regulatory lists and updating standards in line with modern diagnostic methods to facilitate germplasm exchange and support global agriculture.
The precise control of complex reactions is critical for biological processes, yet our inability to design for specific outcomes limits the development of synthetic analogs. Here, we leverage differentiable simulators to design nontrivial reaction pathways in colloidal assemblies. By optimizing over external structures, we achieve controlled disassembly and particle release from colloidal shells.
View Article and Find Full Text PDFUnlabelled: T cells are generally sparse in hormone receptor-positive (HR+) breast cancer, potentially due to limited antigen presentation, but the driving mechanisms of low T cell abundance remains unclear. Therefore, we defined and investigated programs ('gene modules'), related to estrogen receptor signaling (ERS) and immune signaling using bulk and single-cell transcriptome and multiplexed immunofluorescence of breast cancer tissues from multiple clinical sources and human cell lines. The ERS gene module, dominantly expressed in cancer cells, was negatively associated with immune-related gene modules TNFα/NF-κB signaling and type-I interferon (IFN-I) response, which were expressed in distinct stromal and immune cell types, but also, in part, expressed and preserved as a cancer cell-intrinsic mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Development of broad-spectrum antiviral therapies, like 4'-fluorouridine (4'-FlU), is crucial for effectively responding to outbreaks and pandemics caused by emerging viruses, particularly those that cause hemorrhagic fevers, which have seen increasing morbidity and mortality rates.
- 4'-FlU has shown antiviral activity against several hemorrhagic fever viruses in cell cultures and has demonstrated high efficacy in guinea pig models infected with lethal arenaviruses, maintaining its effectiveness at low doses.
- When administered late in infection, 4'-FlU not only resolved clinical symptoms quickly but also showcased its potential as a therapeutic option with a broader application against various viral pathogens.