Publications by authors named "R R Hollins"

Article Synopsis
  • The genomics era has led to the identification of the ERG gene as a new autosomal dominant predisposition factor for bone marrow failure (BMF) and hematological malignancies (HM), crucial for blood cell development and function.
  • Research found several rare ERG variants associated with thrombocytopenia and various forms of HM, showing onset typically before age 40.
  • Functional studies indicated that many ERG variants disrupt its role as a transcription factor, leading to ineffective blood cell production, with implications for clinical diagnosis and treatment strategies for affected patients and families.
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An existing chlorophyll-based model has been updated and re-calibrated using measured data describing Jerlov water types, harvested from the World-wide Ocean Optics Database. This study has provided new chlorophyll concentration data, and used them in conjunction with recently published spectra of absorption and scattering coefficients to create an updated parameter set that describes eight of the 10 Jerlov water types. The updated model is consistent with other data, and it interprets the measured characteristics in terms of underlying properties.

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Inherent optical properties (IOPs) of typical ocean waters have been derived from a worldwide database of measured parameters. The optical quality of the world's oceans can be described in terms of their Jerlov water type, ranging from the clearest Jerlov I to the most turbid Jerlov 9C. These Jerlov classifications are defined in terms of an apparent optical property known as the downwelling diffuse attenuation coefficient ().

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Sleep deprivation is reported in 80% of patients in the intensive care unit (ICU) and is associated with delirium. Guidelines recommend implementing a sleep-promoting protocol in critically ill patients which may increase the quantity and quality of sleep and may decrease delirium. Our objective was to implement a pharmacist-led interdisciplinary sleep-promoting protocol and analyze its impact on delirium in ICU patients receiving mechanical ventilation (MV).

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