Publications by authors named "R R Handley"
Article Synopsis
- * Researchers developed a transgenic sheep model (OVT73) to study HD, which shows early signs of the disease without motor symptoms or cell loss at a young age, aiding in understanding disease onset.
- * A study of the sheep's brain revealed increased expression of certain receptors and transporters, suggesting that excitotoxicity from glutamate may trigger early neurodegeneration, but protective mechanisms could help buffer against cell damage.
The COVID-19 pandemic exposed vulnerabilities in many health systems worldwide with profound implications for health and society. The public health challenges experienced during the pandemic have highlighted the importance of resilient health systems, that can adapt and transform to meet the population's evolving health needs. Essential public health functions (EPHFs) offer a holistic, integrated and sustainable approach to public health by contributing to achieving several health priorities and goals.
View Article and Find Full Text PDFSomatic instability of the huntingtin (HTT) CAG repeat mutation modifies age-at-onset of Huntington's disease (HD). Understanding the mechanism and pathogenic consequences of instability may reveal therapeutic targets. Using small-pool PCR we analyzed CAG instability in the OVT73 sheep model which expresses a full-length human cDNA HTT transgene.
View Article and Find Full Text PDFArticle Synopsis
- * Conducted in Cameroon, the research included 443 participants, revealing a 30.3% prevalence of HD in ulcers and 8.6% in asymptomatic individuals, while Treponema pallidum (TP) was found at a lower rate of 5.2%.
- * Risk factors included gender parity in HD ulcer cases and physical proximity to confirmed cases, with findings indicating that HD is the most common cause of skin ulcers in the studied areas, warranting further research into asymptomatic carriage and disease transmission. *
Article Synopsis
- The study evaluated a group stabilisation intervention for PTSD patients on the waitlist for individual therapy, aiming to ease prolonged suffering due to extended wait times in NHS services.
- Fifty-eight patients participated, and the group therapy was found to be both feasible and acceptable, resulting in medium to large reductions in PTSD symptoms and minimal deterioration in anxiety and depression.
- Preliminary evidence suggests that attending psychoeducational group therapy can be beneficial while waiting for individualized trauma-focused treatment.