Publications by authors named "R R Geraldo"

Group B Streptococcus (GBS) remains the leading bacterial cause of invasive neonatal disease, resulting in substantial morbidity and mortality. New therapeutic approaches beyond antibacterial treatment to prevent neonatal disease outcomes are urgent. One significant limitation in studying GBS disease and progression is the lack of non-invasive technologies for longitudinal studies.

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Article Synopsis
  • This study focuses on creating and testing 6-aminated 1,4-benzoquinones (6-AQs) for their ability to combat seven resistant pathogens.
  • The 6-AQs were synthesized using a reaction between bromoquinone and substituted anilines, and their antimicrobial effectiveness was analyzed, revealing minimum inhibitory concentrations between 16 to 128 μg/ml.
  • Notably, two derivatives showed effectiveness against methicillin-resistant strains, showcasing both bacteriostatic and bactericidal properties and suggesting these compounds as potential new treatments.
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Thirteen years after the publication of the National Policy for the Comprehensive Health of the Black Population (PNSIPN, Política Nacional da Saúde Integral da População Negra), filling out the race/skin color question in the patient identification form remains a challenge. Authors have focused on the need to integrate knowledge from the science of implementation into public policies. The aim of this article is to describe and analyze the implementation of the collection of the race/skin color item carried out by the professionals responsible for the registration of patients at a university hospital in the city of São Paulo.

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  • Group B Streptococcus (GBS) poses a significant risk to newborns, leading researchers to explore glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a possible vaccine target.
  • Vaccinating mothers with GBS GAPDH affects their offspring, resulting in changes to the gut microbiome and immune system development, with observed alterations in inflammatory markers and immune cell expression.
  • Male pups from vaccinated mothers also show long-term behavioral issues, including anxiety-like symptoms and impaired learning and memory, raising concerns about maternal vaccination strategies using common antigens.
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Legume grains have provided essential nutrients in human diets for centuries, being excellent sources of proteins, carbohydrates, fatty acids, and fibers. They also contain several non-nutrients that historically have been connotated as toxic but that in recent years have been shown to have interesting bioactive properties. The discussion on the role of bioactive non-nutrients is becoming more important due to increasing science-based evidence on their potential antioxidant, hypoglycemic, hypolipidemic, and anticarcinogenic properties.

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